关键词:生物制造、生物叁维打印、生物墨水、体外生命系统工程、组织工程、生物材料。
体外生命系统工程是以工程化技术手段构建体外有生命的生物学模型的一门交叉学科,它在生命科学基础研究、疾病诊断/治疗、组织修复/再生等领域,均具有巨大的应用潜力。生物制造是体外生命系统的重要实现手段,特别是以含活细胞生物材料为操控对象的增材制造、模块化组装等技术的发展,以“自下而上”的思想,为构建复杂组织/器官模型提供了更多机会和可能。近年来课题小组在相关领域开展了系统研究,已在Sciences Advances, Advanced Materials, Materials Today等期刊发表系列高质量研究论文,, Google Scholar引用6000余次,H因子27(as of Jan 2026),出版生物3D打印英文专著1本(独作,Springer出版社)。
目前的主要研究方向:
1. 生物制造使能技术创新;
2. 基于细胞动态微环境的材料创新;
3. 面向再生医学与体外生命系统工程的应用创新。
承担的主要课题:
国家自然科学基金生命健康重大专项,20226-2029,承担子任务
国家重点研发青年科学家项目,2024-2029,主持
国家自然科学基金面上项目,2025-2028,主持
国家自然科学基金青年项目,2022-2024,主持
国家自然科学基金国际合作交流项目,2023-2024,主持
国家级青年人才项目,2022-2024,主持
招生招聘:
课题组每年招收博士生,欢迎优秀的推免本科生及硕士生联系咨询。
课题组常年招聘博士后,欢迎具有相关学科背景及研究兴趣的青年人才加盟。
组员招收的重点研究方向:干细胞、类器官、水凝胶生物材料及相关生物工程领域。
Google Scholar:
全文下载:
专着:
1. D. Zhou, C. Wang, A. Hert, L. Yan, B. Dou, and L. Ouyang*, in Multicomponent HydrogelsSmart Materials for Biomedical Applications, ed. J. M. Dodda, K. Deshmukh, and D. Bezuidenhout, The Royal Society of Chemistry, 2023, ch. 8, pp. 231-287.
2. L. Ouyang*, Study on Microextrusion-based 3D Bioprinting and Bioink Crosslinking Mechanisms (Springer, Singapore, 2019). ISBN 978-981-13-9455-3.
代表性研究论文(+共同一作,*通讯作者):
[1] C. Wang, Z. Wang, Y. Lin, L. Ouyang*, Off-the-shelf Granular Microtissue Bioinks: Long-term Preserved Cellularized Porous Microgels with Enhanced Cell Activity for Shelf-ready Biofabrication, Advanced Materials, 37, e06616 (2025).
[2] R. Xu, B. Dou, S. Yu, Z. Wang, Y. Zhang, L. Leng, L. Ouyang*, W. Sun, Enabling 3D printability and vascular morphogenesis with double network dynamic hydrogels. Materials Today, 84, 10-27 (2025).
[3] Y. Guo, Z. Wang, X. Zhang, J. Li, S. Gao, Y. Lv, L. Ouyang*, Microfiber-Templated Porogel Bioinks Enable Tubular Interfaces and Microvascularization Down to the Building Blocks for 3D Bioprinting. Small, 2501594 (2025).
[4] J. Ma, Y. Yang, B. Pei, S. Mi*, Z. Xiong*, L. Ouyang*, Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features, Advanced Science, 12, e02367 (2025).
[5] R. Xu, H. Ooi, L. Bian, L. Ouyang*, W. Sun, Dynamic Hydrogels for Biofabrication: A Review. Biomaterials 320, 123266 (2025)
[6] D. Zhou, P. Li, S. Yu, Z. Cui, T. Xu, L. Ouyang*, Optimizing extrusion-based 3D bioprinting of plant cells with enhanced resolution and cell viability. Biofabrication, 17, 025008 (2025).
[7] L. Ouyang*, J.P. Wojciechowski, J. Tang, Y. Guo, M.M. Stevens*, Tunable Microgel-Templated Porogel (MTP) Bioink for 3D Bioprinting Applications, Advanced Healthcare Materials, 11, 2200027 (2022).
[8] L. Ouyang, J.P.K. Armstrong, Y. Lin, J.P. Wojciechowski, C. Lee-Reeves, D. Hachin, K. Zhou, J.A. Burdick, M.M. Stevens*, Expanding and Optimizing 3D Bioprinting Capabilities using Complementary Network Bioinks. Science Advances, 6, eabc5529 (2020).
[9] L. Ouyang, J.P.K. Armstrong, Q. Chen, Y. Lin, M.M. Stevens*, Void‐Free 3D Bioprinting for In Situ Endothelialization and Microfluidic Perfusion. Advanced Functional Materials 30, 1908349 (2020).
[10] L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick*, A Generalizable Strategy for The 3D Bioprinting of Hydrogels From Nonviscous Photo‐Crosslinkable Inks. Advanced Materials 29, 1604983 (2017).